Background：

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding， transcriptional regulation， and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli， and interacts with p53 and retinoblastoma-1. It modulates p53 function， and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.