Background：

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme， and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein， which has both ubiquitin ligase and deubiquitinase activities， is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.