Background：

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha， beta， gamma). Adducin is a heterodimeric protein that consists of related subunits， which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive， hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast， beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however， not all variants have been fully described.