 |
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|---|---|---|
| 【ProductName】 |
USP30 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K110455P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q70CQ3 |
|
| 【Gene ID】 |
84749 |
|
| 【Application】 |
Blocking Peptide of K110455P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins， such as RHOT1/MIRO1 and TOMM20， thereby blocking parkin’s ability to drive mitophagy (PubMed:18287522， PubMed:24896179， PubMed:25527291， PubMed:25621951). Preferentially cleaves ’Lys-6’- and ’Lys-11’-linked polyubiquitin chains， 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at ’Ser-65’ (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).