Background：

This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex， which associates with transcriptional coactivators， nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain， which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors， such as thyroid hormone receptor and retinoid X receptor alpha， but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1).