Background：

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1)， and induces cell apoptosis. Through its death domain， the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein， which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation， and may be involved in inflammation and immune regulation.