Background：

The protein encoded by this gene is a signal transducer shared by many cytokines， including interleukin 6 (IL6)， ciliary neurotrophic factor (CNTF)， leukemia inhibitory factor (LIF)， and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6， a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus， can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.